Lomustina [INN-Spanish]

• Antineoplastic Agents
• ATC:L01AD02

• Belustine
• CCNU
• CINU
• Cecenu
• CeeNU
• Chloroethylcyclohexylnitrosourea
• Lomustina [INN-Spanish]
• Lomustinum [INN-Latin]

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C₉H₁₆ClN₃O₂

http://www.rxlist.com/cgi/generic2/lomustine.htm

Lomustina_[INN-Spanish] MSDS

Johnston, TP et al;. J.Med.Chem;. 9; 892-911 (1966)

233.695 g/mol

88-90 ^oC

111 mg / L

Solid

2.629

Capsule (10 mg, 40 mg e 100 mg)

Indicato principalmente per il trattamento dei tumori cerebrali. Anche per il trattamento del cancro al seno, malattia di Hodgkin, tumore del polmone, melanoma maligno, mieloma multiplo, non-Hodgkin, il cancro ovarico, tumore al pancreas, e carcinoma renale.

Lomustina è un agente alchilante del tipo nitrosourea. Lomustina e dei suoi metaboliti interferisce con la funzione del DNA e RNA. E 'del ciclo cellulare fase-specifici. Tumori si formano quando alcune cellule all'interno del corpo proliferare in maniera incontrollata e anomalo. Queste cellule poi diffondersi e distruggere i tessuti vicini. Lomustina atti di rallentare questo processo verso il basso. Uccide le cellule tumorali danneggiando il DNA (la genetica materiale all'interno delle cellule) e impedisce loro di dividersi.

Bene e rapidamente assorbito dal tratto gastrointestinale.

Orale, ratto: LD50 = 70 mg / kg. Tossicità polmonare è stata riportata a dosi cumulative di solito maggiore di 1.100 mg/m2. C'è un rapporto di tossicità polmonare ad una dose cumulativa di soli 600 mg. Il insorgenza di tossicità varia da 6 mesi dopo l'inizio della terapia, al più tardi 15 anni dopo.

Lomustine (loe-MUS-teen) is a drug that is used to treat some kinds of cancer.
It is a capsule that you take by mouth.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effects.
It is important to take lomustine exactly as directed by your doctor. Make sure
you understand the directions. You may be given capsules of more than one strength
to make the right dose. Unless your doctor gives you other directions, take all
the capsules as a single dose at bedtime (on an empty stomach with a glass of water).
If you vomit within 45 minutes of taking lomustine, call your cancer doctor the
next morning.
Store lomustine capsules out of the reach of children, at room temperature, away
from heat, light and moisture.
Other drugs may interact with lomustine. Check with your doctor or pharmacist before
you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness
of lomustine.
Lomustine may cause sterility in men and menopause in women which may be permanent.
If you plan to have children, discuss this with your doctor before being treated with
lomustine.
Lomustine may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with lomustine. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are taking lomustine before you receive any treatment
from them.

Gli esseri umani e altri mammiferi